Searchable abstracts of presentations at key conferences in endocrinology

ea0056p1060 | Thyroid (non-cancer) | ECE2018

The efficacy of intrathyroid injected steroids for painful lymphocytic thyroiditis

Paja Miguel , Del Cura Jose L

Thyroidal pain is usually due to subacute thyroiditis. It seldom occurs in patients with Hashimoto’s thyroiditis (HT), and then its name is painful HT (PHT). Differently from subacute thyroiditis, occasional PHT patients show no benefit from medical treatment so that thyroidectomy is frequently needed. We report two women diagnosed of PTH and successfully treated with intrathyroidal corticosteroid injection after initial unsuccessful treatment with L-thyroxine replacement...

ea0041ep1097 | Thyroid cancer | ECE2016

Immunohistochemistry as alternative to DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas

Paja Miguel , Del Cura Jose L , de Ciriza Maite Perez , Oleaga Amelia , Ugalde Aitziber

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

ea0067o57 | Oral Presentations | EYES2019

βeta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

Flores-Guerrero Jose L , Connelly Margery A , Groothof Dion , Gruppen Eke G , Bakker Stephan JL , Dullaart Robin PF

Objective: A potential role for the ketone body beta-hydroxybutyrate (β-OHB) has received increasing interest in the study of metabolic disease, but the association of β-OHB with Type 2 Diabetes (T2D) risk remains unclear. The present study aimed to explore the association of β-OHB with incident T2D in a prospective population-based cohort.Methods: We measured plasma concentrations of β-OHB using nuclear magnetic resonance spectroscop...

ea0073oc7.1 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Circulating concentrations of TMAO is associated with all-cause mortality in subjects with Non-alcoholic fatty liver disease. Results from a dutch prospective cohort

Flores-Guerrero Jose L. , van Dijk Peter R. , Connelly Margery A. , Garcia Erwin , Navis Gerjan , Bakker Stephan J.L. , Dullaart Robin P.F.

ObjectiveDue to the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), it has become a global health challenge by being the most common cause of chronic liver disease. Recently, the microbiota has been linked to NAFLD, via altered bile acid and lipid metabolism. Whether serum Trimethylamine-N-oxide (TMAO), a gut microbiota-dependent metabolite, is associated with NAFLD and NAFLD health outcomes remains unclear. The aim was to investigate...

ea0056p1156 | Thyroid cancer | ECE2018

Diagnostic accuracy of CNB in tyroid nodules smaller than 1 centimeter

Paja Miguel , Ugalde Aitziber , Korta Igone , Zabala Rosa , Martinez Adela L , Zabalegui Alba , Arrizabalaga Cristina , Calles Laura A , Etxebarria Eider , Del Cura Jose L

Current guidelines suggest sonographic follow-up in thyroid nodules smaller than 10 mm with intermediate or highly suspicious features as ultrasound-guided FNAC has poor results in these nodules, and the risk of non-diagnosed thyroid carcinoma is very low. CNB has proved superior to repeated FNAC in case of insufficient or indeterminate first FNAC.Objective: Evaluate diagnostic accuracy of CNB in nodules smaller than 10 mm with intermediate or high suspi...